Fixed combination of losartan and hydrochlorothiazide and reduction of risk of stroke

نویسندگان

  • Sverre E Kjeldsen
  • Paulette A Lyle
  • Jorge R Kizer
  • Suzanne Oparil
  • Aud Høieggen
  • Ingrid Os
چکیده

A fixed-dose combination of losartan/hydrochlorothiazide (HCTZ) therapy may be a logical choice for antihypertensive treatment, including for initial therapy in patients with blood pressure elevation >20/10 mmHg above treatment target. The renin-angiotensin-aldosterone-system-activating effect of hydrochlorothiazide augments the efficacy of blocking the angiotensin II type 1 (AT1) receptor with losartan. Some adverse effects associated with hydrochlorothiazide, including increased risk for new-onset diabetes mellitus, may be offset by losartan. Losartan was frequently administered with hydrochlorothiazide in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study, in which there was a 25% risk reduction for stroke in the losartan-based compared with the atenolol-based treatment group. The efficacy, tolerability, and convenience of losartan/HCTZ combination therapy may increase patient compliance and lower risk for stroke, a devastating outcome in patients with hypertension.

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Simultaneous Determination of Losartan and Hydrochlorothiazide in Pharmaceutical Preparations by Derivative and Ratio Derivative Spectrophotometry

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2007